Drugs That Escape Hepatic Metabolism
J Clin Psychiatry 2012;73(7):e889-e890
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Because this piece has no abstract, we have provided for your benefit the first 3 sentences of tahe full text.
There are several situations in which the hepatic metabolism of drugs may differ from that expected, resulting in possibly compromised efficacy or increased adverse effects. These situations are: When patients are slow or rapid metabolizers; when patients receive co-therapy with metabolic enzyme inducers or inhibitors; and when patients have impaired liver function. This article considers anxiolytic, antidepressant, antipsychotic, mood stabilizer, anticonvulsant, and anti-dementia drugs that are useful in such situations. A few metabolic drug interactions are briefly discussed.