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Understanding the Sleep-Wake Cycle: Sleep, Insomnia, and the Orexin System

J Clin Psychiatry 2013;74(suppl 1):3-20
10.4088/JCP.13011su1c

This Academic Proceedings Supplement to The Journal of Clinical Psychiatry presents the highlights of the planning roundtable teleconference “Understanding the Sleep-Wake Cycle: Sleep, Insomnia, and the Orexin System,” which was held on May 24, 2013. This report was prepared and independently developed by the CME Institute of Physicians Postgraduate Press, Inc., and was supported by an educational grant from Merck & Co., Inc.

The teleconference was chaired by Andrew D. Krystal, MD, MS, Insomnia and Sleep Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina. The faculty were Ruth M. Benca, MD, PhD, Center for Sleep Medicine and Sleep Research, Department of Psychiatry, University of Wisconsin, Madison; and Thomas S. Kilduff, PhD, Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California.

Financial disclosure: Dr Krystal is a consultant for Attentiv, Merck, Novartis, Jazz, Takeda, Sanofi-Aventis, Eisai, Purdue, and Transcept; has received grant/research support from the National Institutes of Health, Teva, Sunovion, Brainsway, Neosync, Janssen, Takeda, Astellas, and ANS St Jude; and has been an expert witness for Somaxon. Dr Benca is a consultant for Merck, and has received grant support from the National Institutes of Health and the Agency for Healthcare Research & Quality. Dr Kilduff has received grant/research support from the National Institutes of Health/National Institute of Neurological Disorders and Stroke, F. Hoffman-LaRoche, CHDI Foundation, and Inscopix, Inc, and has received honoraria from the National Institutes of Health.

The opinions expressed herein are those of the faculty and do not necessarily reflect the opinions of the CME provider and publisher or the commercial supporter.

J Clin Psychiatry 2013;74(suppl 1):3–20 (doi:10.4088/JCP.13011su1c)