The Failure of Evidence-Based Medicine to Guide Treatment of Antidepressant Nonresponders

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Depression is one of the world’s greatest health problems,1 and prompt recognition and vigorous treatment to remission are the best means to reduce the global illness burden, increased mortality, and untold suffering associated with depressive disorders. As I have reviewed elsewhere, dozens of randomized controlled trials (RCTs) have documented that antidepressant pharmacotherapy, the most widely used treatment for depression, has limited efficacy.2–5

J Clin Psychiatry 2006;67(12):1833-1835