Original Research J Clin Psychiatry October 2010

Antidepressants and Body Weight: A Comprehensive Review and Meta-Analysis

JCP 2010;71(10):10.4088/JCP.09r05346blu

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. JCP 2010;71(10):10.4088/JCP.09r05346blu Clinical Summary Weight gain can derail otherwise effective antidepressant treatment and add risk for diabetes mellitus, hypertension, and coronary heart disease. This review matters because antidepressants do not affect body weight uniformly, and the difference between short-term and long-term weight effects can directly shape drug selection for patients already at risk of obesity or weight-related medical illness. FAQ Which antidepressants were most associated with weight gain in this meta-analysis? 10 questions
Key Takeaways The review separated acute treatment from maintenance treatment because weight effects changed over time; fluoxetine showed early weight loss that did not persist, whereas paroxetine shifted from marginal weight loss acutely to weight gain in the medium-long term. 5 takeaways Clinical Guide How should clinicians choose an antidepressant when minimizing body weight change is a major treatment priority? 7 steps
Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

Learn More About Psychedelics in Psychiatry

Explore the Collection
Neural network illustration symbolizing psychedelic research advancements

Subscribe to read
more articles

Subscribe