Original Research J Clin Psychiatry January 2011

Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study: the Netherlands Study of Depression and Anxiety (NESDA)

JCP 2011;72(3):10.4088/JCP.10m06176blu

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. JCP 2011;72(3):10.4088/JCP.10m06176blu Clinical Summary Patients rarely present with a "pure" depressive disorder or anxiety disorder, and missing the second diagnosis can underestimate severity, chronicity, and treatment needs. In this large NESDA cohort, comorbidity was the rule rather than the exception and was linked to more childhood trauma, higher neuroticism, earlier onset, longer symptom duration, and greater symptom severity. FAQ How common was comorbidity between anxiety disorders and depressive disorders in the NESDA cohort? 8 questions
Key Takeaways Diagnostic complexity was substantial: among 1,783 patients with a current depressive or anxiety disorder, 40% had only 1 disorder, 30% had 2 depressive or anxiety disorders, and another 30% had ≥ 3 depressive or anxiety disorders. 6 takeaways Clinical Guide How should clinicians routinely assess for comorbid depressive and anxiety disorders when a patient presents with either syndrome? 7 steps
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