Original Research J Clin Psychiatry January 2026

Effects of a Digital Multidomain Cognitive Intervention in Older People at High Risk of Dementia: A Randomized Clinical Trial

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. Clinical Summary Older adults at high risk of dementia need scalable, low-burden options beyond medications, especially in community settings where long-term face-to-face programs are hard to sustain. This trial tests whether a 6-month WeChat-based multidomain intervention can improve cognition and psychosocial outcomes in a distinctly high-risk older population. FAQ What did this randomized trial find about a digital multidomain intervention for older adults at high risk of dementia? 11 questions
Key Takeaways The trial targeted a distinctly high-risk population rather than unselected older adults: eligibility required an MDRS >79, corresponding to the top 20% risk percentile with hazard ratio=3.2, 95% CI: 2.1–4.8, which supports using multimodal risk stratification when deciding who may benefit most from preventive intervention. 6 takeaways Clinical Guide How can clinicians identify older adults who match this trial's high-risk population for a digital multidomain dementia-prevention intervention? 6 steps Clinical Guide How can clinicians implement the 6-month digital multidomain intervention used for older adults at high risk of dementia? 10 steps
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