Original Research J Clin Psychiatry May 2024

A Pilot Study of High-Frequency Transcranial Magnetic Stimulation for Bipolar Depression

JCP 2024;85(2):10.4088/JCP.23m15056

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. JCP 2024;85(2):10.4088/JCP.23m15056 Clinical Summary Bipolar depression remains difficult to treat, with few approved options and ongoing concern about treatment-emergent affective switching with antidepressants. This study addresses whether a standard high-frequency repetitive transcranial magnetic stimulation protocol can reduce depressive symptoms in bipolar I and bipolar II depression without provoking mania or hypomania. FAQ What did this pilot study find about high-frequency rTMS for bipolar depression? 10 questions
Key Takeaways The protocol mirrored a standard unipolar depression regimen: left DLPFC stimulation at 120% of the subject’s RMT, 10 Hz for a 4-second train with a 26-second intertrain interval, 3,000 pulses per session, 5 times a week for a total of 35 treatments or until remission. 6 takeaways Clinical Guide How should clinicians select and treat adults with bipolar depression using the high-frequency rTMS protocol studied here? 9 steps
Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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