Original Research J Clin Psychiatry December 2025

HIV Diagnosis and Preexposure Prophylaxis (PrEP) Prescription Among Commercially Insured Persons With Bipolar Disorder

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. Clinical Summary Patients with bipolar disorder face elevated HIV risk, yet HIV prevention often sits outside routine psychiatric care. In this national claims analysis, HIV diagnoses continued to accumulate while PrEP use remained strikingly low, highlighting a missed prevention opportunity in a population many psychiatrists see regularly. FAQ How common were new HIV diagnoses among commercially insured people with bipolar disorder in this study? 8 questions
Key Takeaways Among commercially insured people with bipolar disorder, male sex was strongly associated with both incident HIV diagnosis and PrEP receipt, with aOR=5.30 [4.22–6.65] for HIV and aOR=11.6 [10.0–13.5] for any PrEP, suggesting prevention efforts should particularly target men while not overlooking women who may still be at risk. 6 takeaways Clinical Guide How should clinicians identify which patients with bipolar disorder need prompt evaluation for HIV preexposure prophylaxis? 6 steps Clinical Guide How can clinicians incorporate HIV preexposure prophylaxis management into psychiatric care for patients with bipolar disorder? 6 steps
Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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