Original Research J Clin Psychiatry March 2026

Outcomes and Practice Patterns of Long-Acting Injectable Versus Oral Antipsychotics Among Patients With Bipolar I Disorder in the United States: A Hospital Database Analysis

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. Clinical Summary Patients with bipolar I disorder are frequently rehospitalized after discharge, and poor adherence to oral antipsychotics is a persistent clinical barrier. This study addresses whether long-acting injectable antipsychotics are associated with fewer early readmissions in real-world US hospital practice, where their use remains uncommon. FAQ Do long-acting injectable antipsychotics lower rehospitalization rates in bipolar I disorder compared with oral antipsychotics? 11 questions
Key Takeaways LAIs were rarely used at discharge in this hospitalized BD-I cohort: 76,608 (78.1%) received OA at discharge, while only 2,334 (2.4%) received LAI, highlighting a large practice gap despite observed short-term benefits. 6 takeaways Clinical Guide How should clinicians use this study to decide whether to consider a long-acting injectable antipsychotic at discharge for a hospitalized patient with bipolar I disorder? 6 steps Clinical Guide How should clinicians use this study when deciding whether to continue or switch a long-acting injectable antipsychotic after rehospitalization in bipolar I disorder? 5 steps
Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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