Original Research J Clin Psychiatry October 2017

Preventive Effects of Lamotrigine in Bipolar II Versus Bipolar I Disorder

JCP 2017;78(8):10.4088/JCP.16m11404

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. JCP 2017;78(8):10.4088/JCP.16m11404 Clinical Summary Patients with bipolar II disorder often cycle through recurrent depressive and hypomanic episodes, yet most maintenance data for mood stabilizers come from bipolar I disorder. This study addresses a practical prescribing question: whether lamotrigine prevents recurrence/relapse more effectively in bipolar II disorder than in bipolar I disorder in routine clinical care. FAQ Did lamotrigine delay recurrence or relapse longer in bipolar II disorder than in bipolar I disorder? 11 questions
Key Takeaways In this 1-year naturalistic cohort, the 25th percentile time to recurrence/relapse of any mood episode was 71 days in bipolar I disorder versus 183 days in bipolar II disorder, suggesting a clinically meaningful separation in early relapse timing after lamotrigine initiation. 6 takeaways Clinical Guide How should clinicians use this study when deciding whether lamotrigine is an appropriate maintenance treatment for bipolar II disorder? 6 steps Clinical Guide How should clinicians initiate and monitor lamotrigine in bipolar disorder based on the dosing and safety procedures used in this study? 7 steps
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