Academic Highlights J Clin Psychiatry November 2025

Real-World Implementation of Xanomeline-Trospium in Schizophrenia: A Consensus Panel Report

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. Clinical Summary Patients with schizophrenia often need lifelong treatment, yet standard dopamine-blocking antipsychotics leave many with persistent negative or cognitive symptoms and accumulate burdens such as EPS, metabolic effects, and prolactin elevation. This report addresses how clinicians can actually start, titrate, and combine xanomeline-trospium in practice while managing the early gastrointestinal and anticholinergic issues that most affect adherence. FAQ What makes xanomeline-trospium different from standard antipsychotics for schizophrenia? 12 questions
Key Takeaways In the pooled 5-week EMERGENT 1–3 trials, XT separated from placebo on PANSS total and positive subscale scores at the first assessment, while PANSS negative symptom benefits did not reach statistical significance until week 3; this timing can help set expectations for early follow-up. 6 takeaways · 5 clinical pearls Clinical Guide How should clinicians initiate xanomeline-trospium for hospitalized patients with schizophrenia? 5 steps Clinical Guide How should clinicians switch or add xanomeline-trospium when a patient with schizophrenia is already taking an antipsychotic? 6 steps Clinical Guide How should clinicians initiate and titrate xanomeline-trospium for outpatients with schizophrenia? 6 steps PDF Download
Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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