Original Research J Clin Psychiatry April 2024

A Fully Remote Randomized Trial of Transcranial Alternating Current Stimulation for the Acute Treatment of Major Depressive Disorder

JCP 2024;85(2):10.4088/JCP.23m15078

Full Article Read the complete peer-reviewed article in J Clin Psychiatry. JCP 2024;85(2):10.4088/JCP.23m15078 Clinical Summary Patients with major depressive disorder often wait weeks for antidepressant benefit, and access barriers leave many without timely specialty care. This trial asks whether a fully remote, self-administered transcranial alternating current stimulation approach can deliver faster symptom relief with minimal safety burden. FAQ Did at-home transcranial alternating current stimulation work for major depressive disorder in this trial? 10 questions
Key Takeaways The prespecified intent-to-treat primary end point was narrowly missed at 2 weeks despite improvement in both groups: BDI-II change was 16.65 with active treatment and 14.36 with sham, for a between-group difference of 2.04 (1-sided P = .056, 95% CI, −0.476 to 4.549). 6 takeaways Clinical Guide How can clinicians identify appropriate adults with major depressive disorder for at-home transcranial alternating current stimulation and start the treatment regimen used in this trial? 7 steps
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