Original Research Prim Care Companion CNS Disord November 2026

Prescription Patterns in Canadian Operational Stress Injury Clinics: An In-Depth Examination of Posttraumatic Stress Disorder Treatment Practices

PCC CNS Disord 2026;28(6):10.4088/PCC.26m04242

Full Article Read the complete peer-reviewed article in Prim Care Companion CNS Disord. Clinical Summary Patients with military-related posttraumatic stress disorder in operational stress injury clinics often have chronic symptoms, multiple comorbidities, and long prior treatment histories, making straightforward first-line prescribing difficult in day-to-day care. This study shows how psychiatrists in Canadian operational stress injury clinics are actually treating posttraumatic stress disorder, including how often care extends beyond guideline-first antidepressants into polypharmacy and symptom-targeted adjunctive treatment. FAQ What medications were most commonly prescribed for PTSD in Canadian operational stress injury clinics?

Key Takeaways Medication use was nearly universal in this cohort: 432 of 438 patients (98.6%) received at least 1 medication, with a mean of 3.04 (SD = 1.65) PTSD-indicated medications per patient, suggesting that medication reconciliation and cumulative adverse-effect monitoring should be routine in operational stress injury clinics. Clinical Guide How should clinicians structure medication treatment for patients with chronic military-related posttraumatic stress disorder seen in operational stress injury clinics? Clinical Guide How should clinicians review and interpret polypharmacy in patients with posttraumatic stress disorder treated in operational stress injury clinics?