Serum Bupropion Levels in 2 Breastfeeding Mother-Infant Pairs
J Clin Psychiatry 2002;63:910-911
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: These are the first reported data on
bupropion and hydroxybupropion levels in infants whose treated
mothers were breastfeeding. The information will assist
physicians and parents in the risk-benefit decision-making
process for bupropion treatment during breastfeeding.
Method: Serum samples were obtained by
venipuncture from 2 mother-infant pairs. The serum was assayed
for levels of bupropion and its most active metabolite,
Results: Neither infant had quantifiable serum
levels of bupropion or its metabolite at steady state. Neither
infant had medical problems during the time of maternal therapy.
Conclusion: We recommend obtaining and
publishing additional serum level findings for breastfeeding
mother-infant pairs since data for bupropion are favorable but