Cognitive Impairment and Functional Outcome in Schizophrenia and Bipolar Disorder
J Clin Psychiatry 2006;67(suppl 9):3-8
© Copyright 2014 Physicians Postgraduate Press, Inc.
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A considerable amount of evidence supports the relationship between cognitive impairment and
functional outcomes in schizophrenia. Cognitive impairment is considered a core feature of schizophrenia
that includes problems in speed of processing, attention/vigilance, working memory, verbal
learning, visual learning, reasoning and problem solving, and social cognition. These deficits can also
serve as an endophenotype for the illness in studies of genetics. Cognition is considered a reasonable
treatment target in individuals with schizophrenia, partly because cognitive deficits contribute to poor
functional outcomes. Similarly, evidence is beginning to emerge that cognitive impairment may also
be a core feature of bipolar disorder. In addition, cognitive deficits adversely affect functional outcomes
in bipolar disorder. This evidence suggests that cognition can be considered a reasonable target
for intervention in both schizophrenia and bipolar disorder.