Evidence of Switching Antipsychotic Therapy to Improve Metabolic Disturbances
Peter J. Weiden, MD, and John W. Newcomer, MD
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Atypical antipsychotic medications are often prescribed in place of conventional
antipsychotics because these newer agents are associated with a low incidence
of extrapyramidal symptoms (EPS). However, many of the atypical antipsychotics
have adverse metabolic side effects such as substantial weight gain. Weight
gain and other metabolic side effects associated with the atypical antipsychotics
have led to as high an incidence of noncompliance in patients with
schizophrenia as EPS did with the older drugs. Weight gain is also associated
with an increase in risk for diabetes, cardiovascular disease, and
dyslipidemia. It is possible to reverse some of the weight gain associated with
atypical antipsychotics by switching medications. Switching a patient to an
appropriate low-weight-gain antipsychotic can improve weight gain and other
metabolic issues often without risking efficacy.
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J Clin Psychiatry 2007;68(5):e13
© Copyright 2007 Physicians Postgraduate Press, Inc.
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