Effect of Hyperprolactinemia During Development in Children and Adolescents

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Increased levels of prolactin associated with some antipsychotic treatment can potentially lead to serious adverse events including gynecomastia, galactorrhea, oligomenorrhea, amenorrhea, and pituitary tumors. Clinicians may need to employ pharmacotherapeutic interventions such as reducing dosage, switching antipsychotics, or prescribing adjunctive agents to minimize or prevent these negative side effects and improve patients’ outcomes.

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J Clin Psychiatry 2008;69(8):e24