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Please answer the following questions about treating schizophrenia.

1. Mr A, your 35-year-old patient with schizophrenia, has achieved symptomatic remission, but you notice cognitive problems that might be hindering his progress in social and occupational areas. As you determine treatment goals in these areas, what interview-based assessment should you use to best measure Mr A’s cognitive abilities?

Quality of Life Scale (QLS)

UCSD Performance-Based Skills Assessment (UPSA)

Social Skills Performance Assessment (SSPA)

Schizophrenia Cognition Rating Scale (SCoRS)

2. Based on recent evidence, the most promising treatment target to address positive, negative, and cognitive symptoms of schizophrenia focuses on which of the following neurotransmitters?




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Science, Rhetoric, and the End of Psychosis
Andrew James Amos, MBBS

Dr Amos voices his concerns about bias in the early intervention in psychosis literature. He welcomes your comments.

» Read this post

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Schizophrenia: The Role of Dopamine and Glutamate Anissa Abi-Dargham, MD, and Jonathan M. Meyer, MD

New! Learn about dopamine dysfunction in schizophrenia and how glutamate may provide targets for pharmacotherapy.

>>See the entire activity

Residual Symptoms and the Risk of Relapse in Major Depression Michael E. Thase, MD

Discover how residual symptoms increase risk for relapse and how to apply treatment options to achieve asymptomatic remission.

>>See the entire activity

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Articles published electronically 4/15/14

Gender Differences, Clinical Correlates, and Longitudinal Outcome of Bipolar Disorder With Comorbid Migraine

[Abstract] [Full Text] Posted 4/15/14

Extended Release Quetiapine Fumarate in Patients With Major Depressive Disorder: Suicidality Data From Acute and Maintenance Studies

[Abstract] [Full Text] Posted 4/15/14

Effect of Adjunctive l-Methylfolate 15 mg Among Inadequate Responders to SSRIs in Depressed Patients Who Were Stratified by Biomarker Levels and Genotype: Results From a Randomized Clinical Trial

[Abstract] [Full Text] Posted 4/15/14

The Alzheimer’s Prevention Initiative Composite Cognitive Test Score: Sample Size Estimates for the Evaluation of Preclinical Alzheimer’s Disease Treatments in Presenilin 1 E280A Mutation Carriers

[Abstract] [Full Text] Posted 4/15/14

Articles published electronically 3/31/14

Physical Activity Interventions for People With Mental Illness: A Systematic Review and Meta-Analysis

[Abstract] [Full Text] Posted 3/31/14

Articles published electronically 3/7/14

Schizophrenia: Mechanism of Action of Current and Novel Treatments [CME]

[Full Text] [CME Posttest] Posted 3/7/14

Articles published electronically 2/18/14

Agomelatine in Generalized Anxiety Disorder: An Active Comparator and Placebo-Controlled Study

[Abstract] [Full Text] Posted 2/18/14

Articles published electronically 2/4/14

Impact of Once- Versus Twice-Daily Perphenazine Dosing on Clinical Outcomes: An Analysis of the CATIE Data

[Abstract] [Full Text] Posted 2/4/14

The Mental Health Characteristics of Pregnant Women With Depressive Symptoms Identified by the Edinburgh Postnatal Depression Scale

[Abstract] [Full Text] Posted 2/4/14

Articles published electronically 1/21/14

The Relationship Between Affective State and the Rhythmicity of Activity in Bipolar Disorder

[Abstract] [Full Text] Posted 1/21/14

The Relationship Between Bipolar Disorder and Biological Rhythms

[Abstract] [Full Text] Posted 1/21/14

An Exploratory Randomized Controlled Study of a Healthy Living Intervention in Early Intervention Services for Psychosis: the INTERvention to Encourage ACTivity, Improve Diet, and Reduce Weight Gain (INTERACT) Study

[Abstract] [Full Text] Posted 1/21/14

Urinary Tract Infections in Acute Psychosis

[Abstract] [Full Text] Posted 1/21/14

Articles published electronically 1/7/14

National Trends in Second-Generation Antipsychotic Augmentation for Nonpsychotic Depression

[Abstract] [Full Text] Posted 1/7/14

The Use of Prescription Opioid Medication by Patients With Borderline Personality Disorder and Axis II Comparison Subjects: A 10-Year Follow-Up Study

[Abstract] [Full Text] Posted 1/7/14

Articles published electronically 12/24/13

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of S-Adenosyl-l-Methionine (SAMe) Versus Escitalopram in Major Depressive Disorder

[Abstract] [Full Text] Posted 12/24/13

Articles published electronically 12/10/13

A Randomized Trial of Concurrent Smoking-Cessation and Substance Use Disorder Treatment in Stimulant-Dependent Smokers

[Abstract] [Full Text] Posted 12/10/13

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Volume 75March 2014Number 3

Review Article

205 Review of Maintenance Trials for Major Depressive Disorder: A 25-Year Perspective From the US Food and Drug Administration

CME Background

CME Article

263 Posttest


254 A Prospective 4-Year Naturalistic Follow-Up of Treatment and Outcome of 300 Bipolar I and II Patients


CME Commentary

275 Posttest


274 Schizophrenia: The Role of Dopamine and Glutamate [Free Access]

Original Research

215 A Direct, Controlled, Blind Family Study of DSM-IV Pathological Gambling

222 Cost-Effectiveness of Prolonged Exposure Therapy Versus Pharmacotherapy and Treatment Choice in Posttraumatic Stress Disorder (the Optimizing PTSD Treatment Trial): A Doubly Randomized Preference Trial

231 Do Clinical Trials of Treatment of Alcohol Dependence Adequately Enroll Participants With Co-Occurring Independent Mood and Anxiety Disorders? An Analysis of Data From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

238 Weight Change and Metabolic Effects of Asenapine in Patients With Schizophrenia and Bipolar Disorder

247 Trends in Office-Based Mental Health Care Provided by Psychiatrists and Primary Care Physicians

264 Memantine for Fragile X–Associated Tremor/Ataxia Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

276 Latent Class Analysis of Personality Disorders in Adults With Posttraumatic Stress Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions

ASCP Corner

285 The Endocannabinoid System and Schizophrenia: Links to the Underlying Pathophysiology and to Novel Treatment Approaches

Letters to the Editor

288 High-Dose Cholinergic Therapy With Rivastigmine Patch Does Not Prolong QTc Time in Patients With Alzheimer’s Disease

289 The Problem of Patient Heterogeneity and Lack of Proper Training in a Study of EEG Neurofeedback in Children

290 Correction [Free Access]

Online Exclusives

Practical Psychopharmacology

e198 Antidepressants and Testicular Cancer: Cause Versus Association

Original Research

e184 Completed and Attempted Suicides Among 18,154 Subjects With Schizophrenia Included in a Large Simple Trial [Free Access]

e191 Violent and Serious Suicide Attempters: One Step Closer to Suicide?

Book Review

e201 Cognitive-Behavior Therapy for Children and Adolescents

Online Activities

e05 Misdiagnosis of Bipolar Depression in Primary Care Practices [CME]

e06 Common Comorbidities and Differential Diagnosis of Restless Legs Syndrome [CME]

e07 Presentation and Treatment of Complicated Obsessive-Compulsive Disorder [CME]

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The Journal of Clinical Psychiatry is the official journal of the American Society for Clinical Psychopharmacology

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Antidepressants and Testicular Cancer: Cause Versus Association Chittaranjan Andrade
[Full Text With Comments]

Selective Serotonin Reuptake Inhibitor Drug Interactions in Patients Receiving Statins Chittaranjan Andrade
[Full Text With Comments]

Augmenting Selective Serotonin Reuptake Inhibitors With Clomipramine in Obsessive-Compulsive Disorder: Benefits and Risks Chittaranjan Andrade
[Full Text With Comments]

Learning From History: How to Swallow a Pill Chittaranjan Andrade
[Full Text With Comments]

Famotidine Augmentation in Schizophrenia: Hope or Hype? Chittaranjan Andrade
[Full Text With Comments]

Levothyroxine in Psychiatry: Issues Related to Absorption After Oral Dosing Chittaranjan Andrade
[Full Text With Comments]

Antenatal Exposure to Selective Serotonin Reuptake Inhibitors and Duration of Gestation Chittaranjan Andrade
[Full Text With Comments]

Low-Dose Amisulpride and Elevation in Serum Prolactin Chittaranjan Andrade
[Full Text With Comments]

Signal-to-Noise Ratio, Variability, and Their Relevance in Clinical Trials Chittaranjan Andrade
[Full Text With Comments]

Lessons Learned From d-Cycloserine: The Promise and Limits of Drug Facilitation of Exposure Therapy Thomas L. Rodebaugh and Eric J. Lenze
[Full Text With Comments]

Antidepressant Action of Atypical Antipsychotics: Focus on Ziprasidone Monotherapy, With a Few Twists in the Tale Chittaranjan Andrade
[Full Text With Comments]

Augmentation of Venlafaxine With Bupropion: Risks Associated With a Triple Monoamine Reuptake Inhibition Approach to Partially Responsive Depression Chittaranjan Andrade
[Full Text With Comments]

Drug Interactions in the Treatment of Depression in Patients Receiving β-Blocker Drugs Chittaranjan Andrade
[Full Text With Comments]

Drug Interactions in the Treatment of Depression in Patients With Ischemic Heart Disease Chittaranjan Andrade
[Full Text With Comments]

Serotonin Reuptake Inhibitor Treatment of Obsessive-Compulsive Symptoms in Clozapine-Medicated Schizophrenia Chittaranjan Andrade
[Full Text With Comments]

There’s More to Placebo-Related Improvement Than the Placebo Effect Alone Chittaranjan Andrade
[Full Text With Comments]

Breast Cancer and Antidepressant Use Chittaranjan Andrade
[Full Text With Comments]

Modafinil and Armodafinil in Schizophrenia Chittaranjan Andrade
[Full Text With Comments]

Drugs That Escape Hepatic Metabolism Chittaranjan Andrade
[Full Text With Comments]

Practical Psychopharmacology: Schizophrenia and Smoking Chittaranjan Andrade
[Full Text With Comments]

Practical Psychopharmacology: Selective Serotonin Reuptake Inhibitors and Persistent Pulmonary Hypertension of the Newborn Chittaranjan Andrade
[Full Text With Comments]

Commentary: Depression in Women: Windows of Vulnerability and New Insights Into the Link Between Estrogen and Serotonin Sonali Lokuge, Benicio N. Frey, Jane A. Foster, Claudio N. Soares, and Meir Steiner
[Full Text With Comments]

Does DSM-IV Already Capture the Dimensional Nature of Personality Disorders? Mark Zimmerman, Iwona Chelminski, Diane Young, Kristy Dalrymple and Jennifer Martinez
[Full Text With Comments]

A National Epidemic of Unintentional Prescription Opioid Overdose Deaths: How Physicians Can Help Control It Leonard J. Paulozzi, Richard H. Weisler, and Ashwin A. Patkar
[Full Text With Comments]

Editors’ Perspectives: Peer Review and the Evolving Journal

Commentaries on Peer Review and the Evolving Journal. Marlene P. Freeman
[Full Text With Forum]

Peer Review Perspective for Early Career Psychiatrists. Alan J. Gelenberg
[Full Text With Forum]

Learning to Review. Robert Freedman
[Full Text With Forum]

Peer Review by Early Career Psychiatrists: An Opportunity for Development. Anne F. Gross, Ilse R. Wiechers, and Theodore A. Stern
[Full Text With Forum]

The Evolution of the Psychiatry Research Journal. John H. Krystal
[Full Text With Forum]

Peer Review in Early Career: Just Say Yes! Peter P. Roy-Byrne
[Full Text With Forum]

Perspectives on Perinatal Depression Treatment

Perinatal Psychiatry: The Challenges of Making Rational Treatment Decisions at the Interface of Psychiatry and Obstetrics. Marlene P. Freeman
[Full Text With Forum]

Influence of the Media on Women Taking Antidepressants During Pregnancy. Adrienne Einarson
[Full Text With Forum]

The Other Side of the Risk Equation: Exploring Risks of Untreated Depression and Anxiety in Pregnancy. Ellen M. Markus and Laura J. Miller
[Full Text With Forum]

Reflections on Perinatal Depression Treatment. Bryanne Barnett, and Marie-Paule Austin
[Full Text With Forum]

Do We Scare Because We Care? Diane N. Solomon
[Full Text With Forum]

Perinatal Depression: Searching for Specific Tools for a Closer Look at This Window. Claudio N. Soares, and Meir Steiner
[Full Text With Forum]

Psychotherapeutic Treatment Options for Perinatal Depression: Emphasis on Maternal-Infant Dyadic Outcomes. Maria Muzik, Sheila M. Marcus, and Heather A. Flynn
[Full Text With Forum]

No Decision Is Without Risk. Rita Suri, and Lori L. Altshuler
[Full Text With Forum]

The Cost of Restricting Knowledge. Anna R. Brandon, Geetha Shivakumar, Stephen J. Inrig, Simon J. Craddock Lee, and John Z. Sadler
[Full Text With Forum]

Pharmacotherapy or Untreated Antenatal Depression: A False Dichotomy. Sona Dimidjian, and Michael W. O’Hara
[Full Text With Forum]


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Switching Antipsychotic Medications to Reduce Adverse Event Burden in Schizophrenia: Establishing Evidence-Based Practice

John W. Newcomer, Peter J. Weiden, and Robert W. Buchanan

Read this Academic Highlights to receive evidence-based guidance concerning when and how it is appropriate to undertake elective changes in antipsychotic medications in order to reduce adverse effects, particularly those associated with increased long-term health risks.

>>See the entire activity

>>See all available Academic Highlights

Measurement-Based Strategies to Assess and Manage Schizophrenia

Leslie Citrome, MD, MPH (Chair), et al

In this Supplement, discover how to distinguish between primary and secondary negative symptoms, find out how to assess treatment response and functioning, and review new therapeutic targets in the treatment of schizophrenia.

>>See the entire supplement

>>See all available supplements


Outcomes in Bipolar Patients

Christian Simhandl, MD, PhD (Chair), et al

Two-thirds of patients with bipolar disorder relapsed during a 4-year, naturalistic follow-up. The variable with the most protective effect against relapse was that patients not stop or change medication. Explore these and other findings in this CME article.

>>See the entire activity

>>See all Journal CME activities

Prescribing Antidepressants for Bipolar Depression: What Does the Evidence Say?

Susan L. McElroy, MD

Find out why antidepressant monotherapy is not recommended by current guidelines, what risks are associated with their use, and when their use is indicated.

>>See the entire activity

>>See all Multimedia activities

Clinical and Cost Implications of Treating Schizophrenia

John M. Kane, MD (Chair), et al

Read this PEARL 3 InfoPack to explore strategies to enhance cognition in your patients with schizophrenia. Plus, learn about effects of short- and long-term antipsychotics and costs associated with treatment.

>>See the entire activity

>>See all Special Features

Learn. Practice. Treat.

Novel Molecular Targets and Moving Beyond Acute Symptoms in Bipolar Depression

Eduard Vieta, PhD

Review existing medications and learn about new treatments for bipolar depression to help your patients achieve remission.

>>See the entire activity

>>See related activities

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Manuscripts that meet the Journal’s scope and submission criteria are sent to expert consultants for peer review.

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Reviewers who have a financial or personal conflict of interest related to a manuscript are obligated to decline the reviewer position.

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The peer review process is conducted using the electronic submission system used for manuscripts. Potential reviewers are queried in advance about their availability. While reviewers are asked to complete their reviews within 3 weeks of receiving the manuscript, more expeditious turnaround is highly valued. If you would like to be a peer reviewer, please send your CV to .


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Peer review is essential to a medical journal, and each year, those peer reviewers who have carried the heaviest load and reviewed the greatest number of manuscripts are recognized as members of the Journal’s Circle of Honor.

The Circle of Honor is the Journal’s acknowledgment of the indispensable contribution—the dedication, scholarship, and scientific rigor—generously donated by these individuals.

2013 Circle of Honor

Chittaranjan Andrade, MD

Scott A. Freeman, MD

Jerry L. Halverson, MD

Ahmad Hameed, MD

James W. Jefferson, MD

James H. Kocsis, MD

Susan G. Kornstein, MD

Mario Maj, MD

John C. Markowitz, MD

Susan L. McElroy, MD

Roger E. Meyer, MD

J. Craig Nelson, MD

Michael K. Popkin, MD

Jerrold F. Rosenbaum, MD

Barbara O. Rothbaum, PhD

Erika F. H. Saunders, MD

Mauricio Tohen, MD, DrPH

Mark Zimmerman, MD

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