Key Takeaways

  1. Among hospitalized adults with mood disorders, self-poisoning patterns differed by diagnosis: analgesics were more common in MDD than BD (16.7% vs 11%, P = .000), which may help guide means-safety counseling and medication access review.
  2. MDD admissions also showed higher use of other sedatives and hypnotics (4.9% vs 3.7%, P < .001), other and unspecified solid and liquid substances (3.9% vs 3.3%, P = .037), and hanging by strangulation and suffocation (3.7% vs 2.5%, P < .001), suggesting clinicians should ask specifically about both medication stockpiles and nonpharmacologic lethal means.
  3. Not all overdose categories distinguished the groups: tranquilizers/other psychotropic agents were common and nearly identical in MDD and BD (29.2% vs 29.4%, P = .72), as were other specified drugs and medicinal substances (14.3% vs 14.0%, P = .546).
  4. Comorbidity profiles differed in ways that may sharpen inpatient risk assessment: anxiety disorders (41.7% vs 39.7%, odds ratio [OR] = 0.920, CI, 0.864–0.981, P = .011) and adjustment disorders (2.3% vs 1.2%, OR = 0.498, CI, 0.386–0.644, P < .001) were more prevalent in MDD than BD.
  5. BD admissions had greater psychiatric complexity from psychosis-spectrum and personality pathology, with schizophrenia and other psychotic disorders at 6.1% vs 2.6% (OR = 2.486, CI, 2.125–2.909, P = .000) and personality disorders at 27.5% vs 18.5% (OR = 1.670, CI, 1.548–1.802, P = .000).
  6. The inpatient populations were socioeconomically concentrated in lower-income areas, with the highest admission proportions in the 0 to 25th percentile median household income category for both MDD and BD (27.6% vs 31.2%, P < .001), which may be relevant when planning discharge supports and follow-up access.
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