Original Research Prim Care Companion CNS Disord September 2026

Association of Intrusive Posttraumatic Stress Symptoms With Elevated C-Reactive Protein Levels in World Trade Center Responders

PCC CNS Disord 2026;28(5):10.4088/PCC.25m04177

Full Article Read the complete peer-reviewed article in Prim Care Companion CNS Disord. PCC CNS Disord 2026;28(5):10.4088/PCC.25m04177 Clinical Summary Patients with posttraumatic stress disorder often carry a substantial burden of cardiovascular and metabolic risk, and inflammation may be one pathway linking these problems. In World Trade Center responders, this study asks a clinically practical question: which PTSD symptoms track most closely with elevated C-reactive protein after accounting for obesity, lipid levels, and medical comorbidity? FAQ Were PTSD intrusion symptoms linked to higher C-reactive protein levels in World Trade Center responders? 8 questions
Key Takeaways This analysis was conducted a mean 13.6 (SD=1.3) years after September 11, 2001, indicating that the link between posttraumatic stress disorder intrusion symptoms and elevated CRP can persist long after the index trauma in chronic World Trade Center responder cohorts. 5 takeaways Clinical Guide How should clinicians assess elevated inflammatory risk in World Trade Center responders with posttraumatic stress disorder symptoms? 6 steps
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