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International Consensus Group on Depression Prevention in Bipolar Disorder [CME]

J Clin Psychiatry 2011;72(10):1295-1310

Depressive episodes are associated with the greatest disability in patients with bipolar disorder, and patients with the disorder spend a greater amount of time depressed than manic or hypomanic. Mark A. Frye, MD, assembled an international group of experts in psychiatry to review the evidence base for depression treatment and prevention in pa-tients with bipolar disorder. Topics addressed by the group included the evolution of trial design; adverse events of treatment and medical comorbidities associated with bipolar disorder; antidepressant use in bipolar treatment; and the standards of care for bipolar depression prevention in Japan, Korea, Turkey, and Argentina. Recommendations for maintenance treatment and depression prophylaxis in bipolar disorder are discussed, and a guideline of treatment strategies is formulated based on the evidence and clinical experience of the consensus group.