The Journal of
Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

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JCP
Finasteride-Induced Neuropsychiatric Reactions: No Room for Complacency
Letter to the Editor

December 17, 2025

Dr Brezis replies to a letter by Tringali and Tringali regarding his recent article.
JCP
Gestational Exposure to Antidepressants and Neurodevelopmental Disorders in Offspring
Clinical and Practical Psychopharmacology

December 17, 2025

This article reviews 2 meta-analyses and 3 more recent observational studies on gestational exposure to antidepressants and the risk of neurodevelopmental disorders in offspring.
JCP
Fluctuating ADHD Across the Lifespan with Margaret Sibley, PhD
Podcast

December 16, 2025

Dr. Margaret Sibley discusses fluctuating ADHD across the lifespan, insights from the MTA study, and what evolving symptom patterns mean for clinical care.
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Insightful. Evidence-based. Human-centered.

The Journal of Clinical Psychiatry Podcast

Explore the science, practice, and human side of mental health care. Hosted by Dr. Ben Everett, Senior Scientific Director at Physicians Postgraduate Press, the series brings together leading voices in psychiatry, neuroscience, and behavioral medicine to discuss the evidence shaping clinical care today.

Each episode features thoughtful conversations with JCP authors, academic experts, and frontline clinicians exploring disorders across the mental health continuum, from schizophrenia and mood disorders to anxiety, depression, and sleep-related conditions. By bridging research and real-world practice, the podcast delivers insights that empower psychiatrists, nurse practitioners, physician associates, and primary care clinicians to deliver better care for patients with mental illness.

Learn More

 

Explore Special Sections

Focus on Childhood and Adolescent Mental Health Early Career Psychiatrists Focus on Geriatric Psychiatry Focus on Psychotherapy Focus on Psychosis Focus on Suicide Focus on Women’s Mental Health
Figure. Journal cover highlights articles on bipolar II depression therapy, schizophrenia treatment, and adult ADHD symptoms.

Vol 86 • 2025 • Number 4

Read the Current Issue

Original Research

Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults with Bipolar II Depression

Academic Highlights

Real-World Implementation of Xanomeline-Trospium in Schizophrenia: A Consensus Panel Report

Academic Highlights

Psychosocial Interventions and Functional Recovery in Schizophrenia

Original Research

Symptom Network Analysis of ADHD and Emotional Symptoms in Adults

Original Research

Emory Treatment Resistance Interview for PTSD—Short Version

Original Research

Brexpiprazole for the Treatment of Co-Occurring Schizophrenia and Substance Use Disorder
View current Issue

Original Research

JCP
Valproic Acid Use in Females of Reproductive Age
Original Research

December 15, 2025

Approximately 1 in 5 valproic acid (VPA) prescriptions between 2017 to 2022 were prescribed to females of reproductive age. Only 14% of females of reproductive age using VPA were…
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JCP
Obstetric Outcomes of Oral Versus Long-Acting Antipsychotics
Original Research

December 10, 2025

Similar rates of gestational diabetes, eclampsia, preeclampsia, and maternal hypertensive disorders were observed with long-acting injectable and oral second-generation antipsychotics.
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JCP
HIV Diagnosis and PrEP Prescription in Commercially Insured Persons with Bipolar Disorder
Original Research

December 8, 2025

PrEP use among commercially insured people with bipolar disorder was critically low, with fewer than 1% prescribed PrEP.
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Review Articles

JCP
Effectiveness of Peer-Administered Interventions for Perinatal Depression or Anxiety
Meta-Analysis

December 8, 2025

Peer-administered interventions are effective at improving perinatal depression, with peer-delivered psychotherapies being the most effective.
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JCP
Burnout in Psychiatric Doctors Before and After the COVID-19 Pandemic
Meta-Analysis

September 29, 2025

The prevalence of burnout was 37.5% prior to the COVID-19 pandemic and 32.0% following the pandemic.
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JCP
Treating PTSD in Military Populations
Meta-Analysis

March 24, 2025

Integrating psychotherapies and pharmacotherapies may address multiple dimensions of PTSD more effectively than monotherapies.
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JCP
Changes in Cognition in Patients With Schizophrenia
Meta-Analysis

September 25, 2024

Only marginal improvements in cognition were seen over time; the greatest were achieved for patients with an illness duration shorter than 10 years.
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JCP
Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
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JCP
Cognitive Effects of ECT in Schizophrenia: A Review
Review Article

June 5, 2024

ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
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Read articles from ASCP Corner

ASCP Corner

Letters to the Editor

JCP
Burnout in Psychiatric Doctors Before and After COVID-19: A Critical Commentary
Letter to the Editor

December 1, 2025

The authors comment on a recent meta-analysis by Johnson and colleagues.
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JCP
Exposure Therapy for Perinatal OCD: Navigating Evidence and Discomfort
Letter to the Editor

November 17, 2025

Although patients and providers must be prepared for the temporary distress associated with exposure and response prevention, it remains the most effective nonpharmacologic treatment for OCD.
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JCP
From Today’s Observations to Tomorrow’s Standards in Women’s Psychiatry
Letter to the Editor

November 3, 2025

The authors comment on a recent study of treatment use and preference in women with mood disorders.
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JCP
Context Matters in Treatment Preference of Women With Mood Disorders: Reply to Świeczkowski et al
Letter to the Editor

November 3, 2025

The authors reply to Świeczkowski and colleagues’ letter regarding their recent study
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JCP
Racemic Ketamine vs Esketamine in Treatment-Resistant Depression: The Overlooked Role of Arketamine
Letter to the Editor

October 29, 2025

The authors comment on a recent chart review by Meisner et al.
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JCP
Misleading Labeling of S-Methadone as a Novel N-Methyl-D-Aspartate Receptor Antagonist
Letter to the Editor

September 8, 2025

The authors comment on a recent study by Fava et al showing clinical evidence for a long-term antidepressant effect of esmethadone.
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Commentaries

JCP
The Goldilocks Problem: Balancing Internal Validity with Generalizability in Clinical Trials
Commentary

November 26, 2025

The author discusses a recent analysis by Zimmerman and Snyder focusing on the generalizability of PTSD treatment trials.
JCP
MAOI Antidepressants: A History Being Rewritten
Commentary

November 26, 2025

Members of the International MAOI Expert Group discuss historical use of MAOIs, consider their efficacy and safety, and underscore the importance of reassessing their place in treatment algorithms.
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JCP
Gender-Affirming Perinatal Psychiatry for Transgender and Gender Diverse People
Commentary

November 10, 2025

Considerations for providing perinatal psychiatric care to transgender and gender diverse patients are addressed
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JCP
Beyond the Boxed Warning: A Call for Regulation of Psychiatry’s Most Teratogenic Drug
Commentary

October 6, 2025

The authors assert that while valproate remains invaluable for certain severe conditions, the high risk of teratogenicity means stringent safeguards are needed to regulate its use by individuals capable…
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JCP
Why Getting Major Depression Right Matters—For Mothers, Babies, and All of Us
Commentary

September 24, 2025

Commenting on an FDA panel discussion on SSRI use during pregnancy, Dr Payne emphasizes the importance of precision when discussing treatments for mental health conditions.
JCP
Prioritizing Mental Health to Optimize Perinatal, Fetal, and Neonatal Outcomes
Commentary

September 24, 2025

Following an FDA panel discussion on use of SSRIs in pregnancy, the authors highlight the need for balanced conversations and shared decision-making accounting for the risks of untreated disease…
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Weekly Mind Reader: Beyond the Clinic Walls
news

December 19, 2025

This week features a guide for clinicians struggling with career advancement and a case study on balancing ethics and pragmatism.
Antidepressants in Pregnancy Reassessed
news

December 18, 2025

A new review suggests higher autism and ADHD rates after antidepressant use in pregnancy likely reflect factors beyond a direct drug effect.
PCC
Clozapine-Induced Corrected QT-Interval Prolongation and Relationship With Serum Clozapine Concentration
Case Report

December 18, 2025

The author presents a case of clozapine-induced QTc prolongation and discusses its relationship with serum clozapine concentration
ADHD Strengths Tied to Better Wellbeing
news

December 17, 2025

Recognizing and using personal strengths improved wellbeing and mental health in adults, regardless of ADHD status.
Why Some Alzheimer’s Patients Decline Faster Than Expected
news

December 16, 2025

A new study shows that gaps between tau pathology and symptoms can flag faster decline – or unexpected resilience – in Alzheimer’s disease.
PCC
Balancing Pragmatism and Ethics in Psychiatry
Case Report

December 16, 2025

A psychiatrist strategically used a patient’s internalized fear of extremism to redirect behavior during a manic episode.
JCP
Prevalence and 3-Year Outcomes of Mood Disorders
Original Research

November 12, 2025

Lower relapse rates of secondary mood disorders at 3 years suggest a more favorable course when the underlying cause is identified and treated.
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JCP
Acetaminophen Use in Pregnancy and Neurodevelopmental Disorders in Offspring: A Reasoned Evaluation of Risk
Clinical and Practical Psychopharmacology

November 10, 2025

This article considers the background, questions, and evidence related to acetaminophen use in pregnancy and neurodevelopmental disorders in offspring, with reference to two recent large studies.
JCP
Targeting Intolerance of Uncertainty during Pregnancy: A Randomized Controlled Trial to Prevent Postpartum Anxiety Disorders
Original Research

November 5, 2025

A 6-week CBT protocol targeting intolerance of uncertainty significantly reduced the risk of postpartum anxiety disorder onset versus care as usual, and patient satisfaction with treatment was high.
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JCP
The Mission of JCP with Editor-in-Chief Marlene P. Freeman, MD
Podcast

November 4, 2025

Editor-in-Chief Dr. Marlene Freeman discusses the journal’s commitment to evidence-based psychiatry and advancing clinical care.
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JCP
Esketamine Augmented With Dextromethorphan/Bupropion for Treatment Resistant Depression: A Case Series
Case Series

November 3, 2025

Three patients with TRD who had no or partial response to esketamine monotherapy as part of a clinical trial received augmentation with dextromethorphan/bupropion 45 mg/105 mg daily.
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JCP
Retired US Military Veterans and Suicide Risk
Brief Report

October 29, 2025

This analysis found elevated suicide risk for medically retired service members and lower suicide risk for service members who retire based on time in service.
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Consensus Report on XT Use in Practice

Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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