The Journal of
Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

Back to top Open menu arrow
Current Issue Archives Authors Reviewers

Just Published

JCP
The Position of Clozapine in Patients with Treatment-Resistant Schizophrenia: Reply to Mattes
Letter to the Editor

January 28, 2026

Dr Andrade replies to a letter about his article on factors affecting choice of clozapine versus other antipsychotics.
JCP
Developing Algorithmic Psychiatry with Michael Halassa MD, PhD
Podcast

January 27, 2026

,
JCP
Rethinking Amisulpride: Could N-Methylation Result in a New and Even Better Antipsychotic?
ASCP Corner

January 26, 2026

This article will familiarize US clinicians with amisulpride’s history and data, and the rationale behind development of LB-102, an N-methylated analogue of amisulpride.
,

Insightful. Evidence-based. Human-centered.

The Journal of Clinical Psychiatry Podcast

Explore the science, practice, and human side of mental health care. Hosted by Dr. Ben Everett, Senior Scientific Director at Physicians Postgraduate Press, the series brings together leading voices in psychiatry, neuroscience, and behavioral medicine to discuss the evidence shaping clinical care today.

Each episode features thoughtful conversations with JCP authors, academic experts, and frontline clinicians exploring disorders across the mental health continuum, from schizophrenia and mood disorders to anxiety, depression, and sleep-related conditions. By bridging research and real-world practice, the podcast delivers insights that empower psychiatrists, nurse practitioners, physician associates, and primary care clinicians to deliver better care for patients with mental illness.

Learn More

 

Explore Special Sections

Focus on Childhood and Adolescent Mental Health Early Career Psychiatrists Focus on Geriatric Psychiatry Focus on Psychotherapy Focus on Psychosis Focus on Suicide Focus on Women’s Mental Health
Figure. Journal cover highlights articles on bipolar II depression therapy, schizophrenia treatment, and adult ADHD symptoms.

Vol 86 • 2025 • Number 4

Read the Current Issue

Original Research

Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults with Bipolar II Depression

Academic Highlights

Real-World Implementation of Xanomeline-Trospium in Schizophrenia: A Consensus Panel Report

Academic Highlights

Psychosocial Interventions and Functional Recovery in Schizophrenia

Original Research

Symptom Network Analysis of ADHD and Emotional Symptoms in Adults

Original Research

Emory Treatment Resistance Interview for PTSD—Short Version

Original Research

Brexpiprazole for the Treatment of Co-Occurring Schizophrenia and Substance Use Disorder
View current Issue

Original Research

JCP
How Many Criteria Should be Required to Define the DSM-5 Mixed Features Specifier in Depressed Patients?
Original Research

January 21, 2026

In a study of 459 depressed patients, results did not support lowering the DSM-5-TR diagnostic threshold for the mixed features specifier from 3 to 2 criteria.
,
JCP
Geographic Differences in Cannabis Use and Cannabis Use Disorder in the US Veteran Population
Original Research

January 19, 2026

Significant regional differences were observed in cannabis use and cannabis use disorder (CUD). Veterans in the Pacific region had the highest rates of cannabis use and CUD.
, , , et al
JCP
Identifying Optimal Thresholds for Early Opioid Use Frequency in Predicting Buprenorphine Outcomes
Original Research

January 14, 2026

Even very low levels of opioid use in the first 2–3 weeks of buprenorphine treatment signal risk for poor outcomes.
, , , et al

Review Articles

JCP
Effectiveness of Peer-Administered Interventions for Perinatal Depression or Anxiety
Meta-Analysis

December 8, 2025

Peer-administered interventions are effective at improving perinatal depression, with peer-delivered psychotherapies being the most effective.
, , , et al
JCP
Burnout in Psychiatric Doctors Before and After the COVID-19 Pandemic
Meta-Analysis

September 29, 2025

The prevalence of burnout was 37.5% prior to the COVID-19 pandemic and 32.0% following the pandemic.
, ,
JCP
Treating PTSD in Military Populations
Meta-Analysis

March 24, 2025

Integrating psychotherapies and pharmacotherapies may address multiple dimensions of PTSD more effectively than monotherapies.
, , , et al
JCP
Changes in Cognition in Patients With Schizophrenia
Meta-Analysis

September 25, 2024

Only marginal improvements in cognition were seen over time; the greatest were achieved for patients with an illness duration shorter than 10 years.
, , , et al
JCP
Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
, , , et al
JCP
Cognitive Effects of ECT in Schizophrenia: A Review
Review Article

June 5, 2024

ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
,

Read articles from ASCP Corner

ASCP Corner

Letters to the Editor

JCP
Urological Commentary on Ketamine-Associated Uropathy
Letter to the Editor

January 26, 2026

The author comments on a recent article reviewing ketamine-associated uropathy in therapeutic and nontherapeutic settings.
JCP
Ketamine-Associated Uropathy in Therapeutic Contexts: Reply to Abdelrahman
Letter to the Editor

January 26, 2026

Dr Andrade responds to a letter commenting on his recent review of ketamine-associated uropathy in therapeutic and nontherapeutic settings.
JCP
Reframing the Discussion on Finasteride and Neuropsychiatric Safety
Letter to the Editor

December 17, 2025

The authors comment on a recent article by Brezis, who argues that finasteride is causally linked to depression, suicidality, and other neuropsychiatric reactions.
,
JCP
Finasteride-Induced Neuropsychiatric Reactions: No Room for Complacency
Letter to the Editor

December 17, 2025

Dr Brezis replies to a letter by Tringali and Tringali regarding his recent article.
JCP
Burnout in Psychiatric Doctors Before and After COVID-19: A Critical Commentary
Letter to the Editor

December 1, 2025

The authors comment on a recent meta-analysis by Johnson and colleagues.
,
JCP
Exposure Therapy for Perinatal OCD: Navigating Evidence and Discomfort
Letter to the Editor

November 17, 2025

Although patients and providers must be prepared for the temporary distress associated with exposure and response prevention, it remains the most effective nonpharmacologic treatment for OCD.
, ,

Commentaries

JCP
Precision Medicine for Suicide Prevention: It’s Time to Take the Next Step
Commentary

December 22, 2025

The authors recommend moving toward a precision medicine approach to suicide prevention that considers the person, their circumstances and biology, treatment delivery context, and conditions that contribute to the…
, , , et al
JCP
The Goldilocks Problem: Balancing Internal Validity with Generalizability in Clinical Trials
Commentary

November 26, 2025

The author discusses a recent analysis by Zimmerman and Snyder focusing on the generalizability of PTSD treatment trials.
JCP
MAOI Antidepressants: A History Being Rewritten
Commentary

November 26, 2025

Members of the International MAOI Expert Group discuss historical use of MAOIs, consider their efficacy and safety, and underscore the importance of reassessing their place in treatment algorithms.
, , , et al
JCP
Gender-Affirming Perinatal Psychiatry for Transgender and Gender Diverse People
Commentary

November 10, 2025

Considerations for providing perinatal psychiatric care to transgender and gender diverse patients are addressed
, ,
JCP
Beyond the Boxed Warning: A Call for Regulation of Psychiatry’s Most Teratogenic Drug
Commentary

October 6, 2025

The authors assert that while valproate remains invaluable for certain severe conditions, the high risk of teratogenicity means stringent safeguards are needed to regulate its use by individuals capable…
, , , et al
JCP
Why Getting Major Depression Right Matters—For Mothers, Babies, and All of Us
Commentary

September 24, 2025

Commenting on an FDA panel discussion on SSRI use during pregnancy, Dr Payne emphasizes the importance of precision when discussing treatments for mental health conditions.

More JCP Articles

JCP
Next-Step Treatment Options for Treatment-Resistant Depression
Consensus Statement

January 21, 2026

Strong consensus emerged for augmentation with second-generation antipsychotics, TMS, and ketamine/esketamine in the base vignette. Preferences shifted to include non-augmentative antidepressants and ECT based on patient characteristics.
, , , et al
JCP
Thank You to the JCP Community
Editorial

January 19, 2026

Marlene P. Freeman, Editor in Chief, expresses gratitude to JCP’s editors, editorial board members, peer reviewers, authors, and readers.
JCP
The Psychedelic Renaissance and Treatment-Resistant Depression with David Feifel, MD, PhD
Podcast

January 13, 2026

,
JCP
Video Therapy Habit Reversal Training for Body-Focused Repetitive Behaviors
Original Research

January 12, 2026

Large treatment effects and improvements across the lifespan for trichotillomania and excoriation disorder suggest this delivery format may address barriers to evidence-based care.
, , , et al
JCP
Innovation in Psychiatric Drug Development: A Quantitative Analysis of FDA-Approved Psychiatric Drugs, 2012–2024
Original Research

January 12, 2026

Innovation in psychiatric drug development in the past 13 years was limited, with most new drugs representing incremental advances rather than groundbreaking innovations.
, , , et al
JCP
Pregabalin in Pregnancy: Major Congenital Malformations, Other Birth Outcomes, and Neurodevelopmental Outcomes
Clinical and Practical Psychopharmacology

January 7, 2026

About 0.04%-0.14% of women may use pregabalin during pregnancy. This article examines outcomes of pregnancies that were exposed to gabapentin.
JCP
Exercise Reduces Dysphoria in Clinical High-Risk for Psychosis: A Randomized Controlled Trial
Brief Report

January 7, 2026

Dysphoric mood was significantly reduced after an exercise intervention that included included high-impact treadmill interval training; there were no significant changes in other general symptoms.
,
JCP
Digital Cognitive Intervention in Older People at Risk of Dementia
Original Research

January 7, 2026

A 6-month digital multi-domain intervention enhanced general cognitive function and visuospatial memory and reduced loneliness in older adults at high risk for dementia.
, , , et al
JCP
Rechallenge of Lamotrigine After Rash: A Systematic Review
Systematic Review

December 31, 2025

Lamotrigine has been rechallenged safely in select cases, but it is critical to confirm that the initial rash did not have specific features of a severe rash in order…
, , , et al
JCP
Psychiatric Hospitalization and Suicide Attempts in Healthcare Professionals
Original Research

December 31, 2025

Daily suicidal ideation and severe sleep disturbances were found to synergistically elevate suicide risk among healthcare professionals.
, , , et al
JCP
Dr Michael Asbach on the Evolution of PAs in Psychiatry
Podcast

December 30, 2025

Physician Assistant Dr. Michael Asbach addresses workforce solutions in psychiatry, from PA training and autonomous collaboration models to recent UK policy debates. Learn how interdisciplinary teams can expand access,…
,
JCP
Gestational Exposure to Antidepressants and Neurodevelopmental Disorders in Offspring
Clinical and Practical Psychopharmacology

December 17, 2025

This article reviews 2 meta-analyses and 3 more recent observational studies on gestational exposure to antidepressants and the risk of neurodevelopmental disorders in offspring.

Consensus Report on XT Use in Practice

Read the full report
Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

Subscribe to read
more articles

Subscribe