JCP Weekly May 15, 2018

Meta-Analysis

Increasing Antidepressant Dose After Initial Treatment Failure

If an antidepressant doesn't seem to be working, what is your next move? This meta-analysis compares efficacy and tolerability of increasing antidepressant dose versus continuing the initial dose. Read the article to see if the evidence supports switching to a higher dose.

DOI: 10.4088/JCP.17r11693 | Posted: 05/15/2018

Original Research

Antidepressant-Induced Mania in Bipolar Disorder

The use of antidepressants in the treatment of bipolar disorder can lead to antidepressant-induced mania (AIM)—but not in every case. This article explores the risk factors that might increase the risk of AIM in patients with this disorder.

DOI: 10.4088/JCP.17m11765 | Posted: 05/15/2018

Original Research

MIN-101 and Cognition in Schizophrenia Patients

The currently available dopamine-blocking antipsychotics haven't been of much help with cognitive deficits in schizophrenia. This post hoc analysis of an RCT examines whether MIN-101, which combines sigma-2 and serotonin-2A antagonism, might improve cognition in individuals with moderate to severe negative symptoms.

DOI: 10.4088/JCP.17m11753 | Posted: 05/15/2018

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