The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

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Empowering mental health professionals with peer-reviewed psychiatric research and insights

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More JCP Articles

JCP
Early Ketamine Response Reduces Suicidal Events at 3 Months
Original Research

July 23, 2025

Patients whose suicidal ideation responded to ketamine treatment at 7 days after a suicidal crisis had 75% lower odds of experiencing suicidal events at 3 months.
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JCP
Niacin-Induced Response in Early Psychosis
Original Research

July 21, 2025

The authors found that niacin-induced skin flushing response attenuation can serve as a valuable early marker for psychosis.
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JCP
Klotho and Matrix Metalloproteinase-9 Levels and Their Association with Inhibitory Dyscontrol in Adolescents with First-Episode Major Affective Disorders
Original Research

July 16, 2025

Adolescents with bipolar disorder and those with MDD had significantly lower Klotho levels compared with the control group; those with bipolar disorder had the highest MMP-9 levels, followed by…
, , , et al
JCP
Actigraphy-Measured Sleep/Wake Characteristics Associated With Suicidal Ideation in Older Adults With Depression and High Suicide Risk
Original Research

July 14, 2025

Measures of sleep/wake rhythm disruption were independently associated with higher level of suicidal ideation in this sample of older adults at high risk for suicide.
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JCP
Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
Original Research

July 14, 2025

History of ECT use (lifetime and current episode) or TMS use (current episode) was prognostic of poorer outcomes across the total sample and superior benefit from active versus sham…
, , , et al
JCP
VEGF and Other Biomarkers in Cognition of First Episode Psychosis
Original Research

July 9, 2025

VEGF levels were significantly higher in the first-episode psychosis group than in the control group. The preliminary results suggest that increase in VEGF might help preserve social cognition after…
, , , et al
JCP
A Case Series of Intimate Partner Violence in Older Adults
Original Research

July 9, 2025

This case series highlights the complexity in assessing and managing IPV in both members of the older adult dyad. Specific approaches are required given the interdependency often present in…
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JCP
A Primer on Individual Participant Data Meta-Analysis and Its Strengths and Limitations
Clinical and Practical Psychopharmacology

July 7, 2025

This article discusses individual participant data meta-analysis, which differs from conventional meta-analysis in that the statistical team obtains and processes individual participant data from the source studies.
JCP
Global Population-Based Study on the Association Between Ketamine and Esketamine with Suicidality Using WHO VigiBase
Original Research

July 7, 2025

The results do not provide causal evidence of worsening suicidality in persons receiving esketamine/ketamine; mixed results of increased and decreased risk of suicidality were reported with both agents.
, , , et al
JCP
Zuranolone for Postpartum Depression in Real-World Clinical Practice
Case Report

July 2, 2025

Three cases of successful treatment of postpartum depression with zuranolone are presented and discussed.
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JCP
Using GenAI to Train Mental Health Professionals in Suicide Risk Assessment
Original Research

June 30, 2025

This preliminary study suggests that AI-Based Simulators show promise for improving mental health professionals’ self-efficacy in suicide risk assessment.
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JCP
Differentiating Subtypes of MDD Using Serum Biomarkers
Original Research

June 23, 2025

Significant differences in biomarker profiles were observed across MDD subtypes: the melancholic subtype showed higher cortisol levels and lower serotonin levels, and the atypical subtype showed elevated levels of…
, , , et al

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