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More JCP Articles
Original Research
Aripiprazole or Bupropion Augmentation vs Switching to Bupropion in Treatment Resistant Depression
September 22, 2025
In this model, augmentation with bupropion better balanced efficacy and tolerability in TRD in adults under 85 than did switching to bupropion or augmentation with aripiprazole. Augmentation with aripiprazole…
Original Research
Comparative Effects of Repeated Ketamine Infusion vs Intranasal Esketamine in Patients with Treatment Resistant Depression: A Retrospective Chart Review
September 22, 2025
In this naturalistic sample of patients with similarly severe treatment resistant depression treated over a 4- to 5-week induction period, intravenous racemic ketamine was associated with more rapid response…
Original Research
Relationships between Prenatal Body Composition and Mental Health Are Moderated by Physical Activity and Diet
September 15, 2025
Higher body fat mass during pregnancy is associated with more depression and anxiety symptoms. However, physical activity and adherence to high-quality diets can lessen these effects.
Clinical and Practical Psychopharmacology
Ketamine-Associated Uropathy During Therapeutic and Nontherapeutic Use
September 10, 2025
Higher doses, more frequent dosing, longer treatment duration, and oral administration are potential risk factors for ketamine-associated uropathy in maintenance therapy.
Commentary
Practitioners Providing Care for Persons with Severe Mental Disorders Should Routinely Screen for Metabolic Dysfunction–Associated Steatotic Liver Disease
September 10, 2025
Persons with severe mental illnesses should be routinely screened for MASLD as part of a psychiatric and medical assessment that includes social and economic determinants of health, risk factors…
