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Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
Knowledge of ECT for Catatonia
Letter to the Editor

September 11, 2025

The authors comment on a recent study by Kaur et al assessing what internists and neurologists know about catatonia.
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PCC
Mental Health Impact of COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-sectional, Comparative Study
Original Research

September 11, 2025

Older adults were found to have less depression and anxiety compared to middle-aged adults; loneliness and perception of knowledge about COVID can affect the association between the presence of…
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PCC
Knowledge of Catatonia: Reply to Espinoza and Kellner
Letter to the Editor

September 11, 2025

The authors reply to a letter to the editor commenting on their article.
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PCC
Precision Psychiatry for Depression Treatment
Narrative Review

September 9, 2025

Novel precision medicine tools in depression aim to identify the optimal treatment for each patient and have the potential to significantly improve depression management by guiding treatment selection for…
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PCC
Navigating Bell’s Mania and Catatonia
Case Report

September 9, 2025

A healthy 17-year-old boy with no psychiatric family history experienced stress-induced, acute-onset catatonia and Bell’s mania.
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PCC
Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use
Narrative Review

September 4, 2025

Incretin therapies have emerged as a promising treatment option with potential benefits for mitigating cardiometabolic side effects associated with antipsychotics; however, clinical trials have often excluded psychiatric populations.
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Vol 27 • 2025 • Number 4

Read the Current Issue

Letter to the Editor

Knowledge of ECT for Catatonia

Original Research

Predictors of Depression Response in a Community ECT Clinic

Original Research

Medical Student Reactions to Interviewing Psychiatric Inpatients

Review Article

Climate Change and Mental Health

Rounds in the General Hospital

Management of Functional Neurological Disorder

Rounds in the General Hospital

PTSD Management in Primary Care
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Rounds in the General Hospital Rounds from Banner Alzheimer's Institute

Original Research

PCC
Conflict Mediation by CBT
Original Research

June 26, 2025

This study tested the effectiveness of the want/can/must strategy to mediate conflicts, in which the psychotherapist, a specialist in cognitive-behavioral therapy, acts as a facilitator.
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PCC
Readability of Bipolar Disorder Measures
Original Research

June 26, 2025

Readability of self-assessment measures should be at or below a sixth grade reading level to be suitable for the general population.
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PCC
Absconding During Psychiatric Inpatient Treatment
Original Research

May 13, 2025

The study highlights the importance of early risk identification, increased supervision during high-risk periods, and tailored interventions addressing clinical and organizational factors associated with absconding.
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Review Articles

PCC
Efficacy of GLP-1 Agonists in Mental Disorders
Review Article

June 10, 2025

Current evidence underscores the potential of GLP-1 receptor agonists as a novel therapeutic approach for certain psychiatric disorders, particularly AUDs, depression, and autism-related food behaviors.
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PCC
Role of GLP-1 Receptor Agonists in AUD
Narrative Review

May 15, 2025

The authors examine the potential benefits, dosages, and mechanisms of GLP-1 receptor agonists on alcohol consumption and how they can potentially modify alcohol-seeking behavior.
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PCC
Quality Indicators in Community Mental Health Services: A Scoping Review
Review Article

April 8, 2025

Engaging communities in mental health initiatives can improve understanding and support for individuals with mental health disorders and improve quality of the service.
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PCC
Dextromethorphan-Quinidine for Agitation in Dementia
Narrative Review

November 14, 2024

The authors provide an updated summary of the literature on dextromethorphan-quinidine for the treatment of agitation in patients with dementia.
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PCC
Improving Collaboration Between Neuropsychology and Primary Care
Narrative Review

October 31, 2024

Collaboration between neuropsychologists and physicians significantly improves patient care by enhancing diagnostic precision and treatment planning. Read on to find out more.
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PCC
Understanding the Child and Adolescent Mental Health Crisis
Narrative Review

October 24, 2024

The authors delve into current mental health challenges facing children and youth, examining perspectives from both pre-pandemic and pandemic periods.
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Rounds in the General Hospital

PCC
Gastrointestinal Complications of Clozapine
Rounds in the General Hospital

August 12, 2025

Clozapine-induced gastrointestinal hypomotility is common, and it can progress to severe and potentially life-threatening complications;
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PCC
Managing Psychotropic Medication–Induced Priapism
Rounds in the General Hospital

July 31, 2025

A 30-year-old man with schizoaffective disorder presented to the ED with a prolonged, painful erection of spontaneous onset. His current medications included long-acting injectable paliperidone palmitate, valproic acid, and…
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PCC
FND in Active-Duty Military Personnel and Veterans
Rounds in the General Hospital

July 24, 2025

The most common presentations of functional neurologic disorder are functional seizures and functional movement disorders, including paresis. Other common manifestations are somatosensory or visual symptoms and speech disorders.
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PCC
Serious Suicide Attempt Management
Rounds in the General Hospital

July 8, 2025

Approximately half of the individuals who take their own life have had contact with their primary care provider within the month before their death.
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PCC
Time-Limited Teaching of Psychiatry to Medical Students
Rounds in the General Hospital

June 17, 2025

Educational practices such as a “flipped classroom” or “layered learning” can allow the educational experience to be better tailored to the needs of learners.
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PCC
Facing Intensive Care: A Guide for PCPs
Rounds in the General Hospital

June 17, 2025

Critically ill patients develop complex problems that involve affective, behavioral, cognitive, and motor manifestations, and failure to attend to these signs and symptoms can jeopardize the safety of both…
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Case Reports

PCC
Neurobehavioral Symptoms and Machado Joseph Disease
Case Report

September 2, 2025

The authors highlight the neuropsychiatric symptomology of Machado Joseph Disease and how management may be approached in older adult patients who might struggle with similar acute-onset psychiatric concerns.
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PCC
It Takes a Village: A Multidisciplinary Approach to Catatonia in Pregnancy
Case Report

August 26, 2025

Timely treatment of catatonia is crucial and outweighs the risk of exposure to the fetus.
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PCC
Psychosis Due to Cushing Syndrome
Case Report

August 21, 2025

Acute psychosis may be the initial manifestation of Cushing syndrome, but it can easily be overlooked, especially in patients with preexisting psychiatric conditions.
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PCC
Two Cases of Menstrual Psychosis
Case Report

August 19, 2025

Menstrual psychosis is not included in any current nosological system, posing challenges to clinicians for its identification, management, and prognosis.
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PCC
Cerebral Amyloid Angiopathy Presenting as Psychosis
Case Report

August 14, 2025

A 75-year-old woman who was on regular treatment for hypertension for the past 10 years with no history of psychiatric illness or substance use, presented with auditory, visual, and…
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PCC
Neuropsychiatric Manifestation of Tick-Borne Disease
Case Report

August 14, 2025

This case highlights the need for timely screening and treatment of Lyme disease and other tick-borne co-infections in patients with neuropsychiatric symptoms in tick-endemic areas.
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Letter to the Editor

PCC
Reversible Cerebral Vasoconstriction Syndrome and Marijuana
Letter to the Editor

July 22, 2025

The authors raise awareness of a potential complication of extensive marijuana use.
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PCC
Onco-Psychopharmacology: Is Mirtazapine a Catholicon?
Letter to the Editor

June 24, 2025

The author discusses the role of mirtazapine in the treatment of depression in patients with cancer.
PCC
Community-Based Alternatives in Behavioral Crisis Transport
Letter to the Editor

June 12, 2025

Law enforcement transport for individuals in behavioral health crises results in significant financial costs and psychological trauma, reinforcing criminalization and stigma while worsening mental health conditions.
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PCC
Revisiting Ayahuasca: Vine of the Soul of the Amazon
Letter to the Editor

March 18, 2025

The authors comment on a case report previously published in the PCC describing psychosis and ayahuasca use and discuss the need for further research given its increased usage worldwide.
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PCC
Cannabis Withdrawal Psychosis
Letter to the Editor

March 13, 2025

Dr Gorelick comments on a case report recently published in the PCC.
PCC
Cannabis Withdrawal Psychosis: Reply to Gorelick
Letter to the Editor

March 13, 2025

The authors reply to a letter to the editor commenting on their case report.
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More Articles from The Primary Care Companion for DNS Disorders

PCC
Sudden Confusion With Divalproex
Case Report

August 7, 2025

A patient with dementia who resided in a long-term care facility was being treated with multiple psychotropic medications for behavioral issues, but her symptoms of aggression, tremulousness, and restlessness…
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PCC
A Community-Based Approach to Dementia Care
Brief Report

August 7, 2025

The authors describe the identification and management of dementia patients in 4 community psychiatry clinics in India.
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PCC
Beyond the Brain: Unilateral Abdominal Seizures as a Manifestation of Neurocysticercosis
Case Report

August 5, 2025

A 14-year-old boy, with no significant past medical or psychiatric illness was referred for psychiatry evaluation for chief complaints of sporadic, brief episodes of involuntary, painless abdominal movements on…
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PCC
Fluphenazine-Induced Delusion of Pregnancy
Case Report

July 31, 2025

A 32-year-old woman with schizophrenia developed delusions of pregnancy following the initiation of fluphenazine monotherapy.
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PCC
High-Dose Oral Thyroxine Before ECT
Case Report

July 29, 2025

ECT administration in patients with thyroid dysfunction poses unique challenges. While thyroid dysfunction itself can precipitate psychiatric symptoms and catatonia, its effect on cardiovascular function can pose a risk…
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PCC
Bipolar Disorder Preceding PTC Diagnosis
Case Report

July 17, 2025

This case highlights the challenges of managing bipolar disorder in the context of an incidental diagnosis of papillary thyroid carcinoma
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PCC
Safety of ECT in Severe Thrombocytopenia
Case Report

July 15, 2025

Due to the lack of published guidelines, psychiatrists may face challenges weighing risks and benefits of ECT in patients with severe thrombocytopenia.
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PCC
Solitary Rectal Ulcer Syndrome in a Patient Taking Fluoxetine
Case Report

July 15, 2025

A 23-year-old man who was taking fluoxetine presented with rectal bleeding. After evaluation, he was diagnosed with solitary ulcer of the rectum.
PCC
Mental Health Effects of Tirzepatide
Case Report

July 10, 2025

The authors describe 2 cases demonstrating the potential mental health benefits of tirzepatide, a GLP-1/GIP receptor agonist.
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PCC
The Hidden Perils of Kratom
Case Report

July 8, 2025

This case highlights the toxic effects of high-dose kratom and subsequent management using second-generation antipsychotics
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PCC
Tirzepatide for Clozapine-Induced Weight Gain
Case Report

July 8, 2025

The authors describe a patient with schizophrenia who effectively reversed substantial clozapine-induced weight gain using tirzepatide, followed by weight regain after insurance-related discontinuation.
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PCC
WKS Due to Hyperemesis Gravidarum
Case Report

July 3, 2025

A 31-year-old woman presented with perceptual disturbances in visual and auditory modality for 6 years following hyperemesis gravidarum.
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