The Primary
Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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More Articles from The Primary Care Companion for DNS Disorders

PCC
Tacrolimus-Induced Parasomnia Posttransplantation
Case Report

March 17, 2026

The authors present a rare case of tacrolimus-induced parasomnia, adding to the body of evidence on its neurotoxic potential.
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PCC
Clozapine-Induced Antiphospholipid Syndrome
Case Report

March 12, 2026

A 68-year-old man with no pre‐existing risk factors experienced clozapine-induced antiphospholipid syndrome and a deep vein thrombosis.
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PCC
Ultra–Low-Dose Mirtazapine for Chronic Insomnia
Original Research

March 10, 2026

In patients with insomnia disorder, a clinically relevant effect was seen with low-dose mirtazapine (3.75 mg) on insomnia severity from 1–3 months.
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PCC
Caffeine for ICI Encephalitis
Case Report

March 5, 2026

With the increased use of immune checkpoint inhibitors, the potential for aseptic encephalitis poses a unique challenge to patient rehabilitation.
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PCC
Misophonia With Psychiatric Comorbidities
Case Report

March 3, 2026

This case highlights the need for enhanced recognition of misophonia, integrated care pathways, and improved mental health infrastructure in low- and middle-income countries.
PCC
Depression and Cardiovascular Disease in Aging Populations
Original Research

March 3, 2026

Even infrequent depressive symptoms are associated with elevated CVD risk in older adults, and those with both depressive symptoms and obesity or smoking have higher odds.
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PCC
Intranasal Tapentadol Dependence
Case Report

February 26, 2026

The authors present 2 cases of intranasal tapentadol dependence marked by rapid tolerance and significant physical and psychological issues.
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PCC
Practice Relevance as the North Star: A Message From the Editor
Editorial

February 26, 2026

Dr Culpepper, Editor in Chief, outlines manuscript selection criteria for the PCC, prioritizing clinical relevance to primary care and frontline psychiatric settings, and thanks peer reviewers for their service.
PCC
Measurement-Based Care for Bipolar Disorder
Brief Report

February 24, 2026

In patients receiving MBC for bipolar disorder in primary care, treatment changes were more common in the presence of elevated symptoms.
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PCC
Validation of the APREMDI Scale for Brazilian Portuguese
Original Research

February 19, 2026

The APREMDI scale allows clinicians to quantitatively assess patients’ perceptions of respect and dignity during hospitalization, helping to identify subtle dignity violations that may compromise recovery and satisfaction.
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PCC
Calcineurin Inhibitor–Induced Psychosis
Case Report

February 17, 2026

The authors report a case of delayed and recurrent calcineurin inhibitor–induced psychosis with both tacrolimus and cyclosporine, highlighting the need to better understand host vulnerability and risk stratification.
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PCC
Arm EMG and Detection of REM Sleep Without Atonia
Case Report

February 17, 2026

This case highlights the importance of utilizing arm EMG to accurately detect REM sleep without atonia, as REM sleep behavior disorder often precedes the development of α-synucleinopathies, such as…
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