Clozapine Versus Risperidone in Treatment-Refractory Schizophrenia: Possible Impact of Dosing Strategies

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Letter to the Editor

Sir: We read with interest the recent article by Lindenmayer et al. concerning the comparison of clozapine versus risperidone in 35 treatment-refractory schizophrenic patients. In the 12-week open-label study, both medications were effective across a wide spectrum of psychopathologic measures, with clozapine being numerically superior to risperidone. In addition, clozapine was associated with fewer extrapyramidal side effects.

J Clin Psychiatry 1999;60(7):487-488