Can Long-Term Antidepressant Use Be Depressogenic?

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Letter to the Editor

Sir: We appreciated the thoughtful review on the loss of antidepressant efficacy by Byrne and Rothschild. We would like to put forward another possible explanation for the observation: long-term antidepressant use may be depressogenic. While this idea seems counterintuitive, there are reasons to seriously consider it.

J Clin Psychiatry 1999;60(4):263