A Preliminary Study of fMRI-Guided rTMS in the Treatment of Generalized Anxiety Disorder: 6-Month Follow-Up

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Letter to the Editor

Sir: In our recent article, we investigated the effects of functional magnetic resonance imaging (fMRI)-guided repetitive transcranial magnetic stimulation (rTMS) treatment for symptoms of generalized anxiety disorder (GAD). We found that low-frequency rTMS treatment, administered with frameless stereotaxy on the basis of individual functional imaging data, significantly decreased anxiety symptoms associated with GAD. However, when the article was published, the duration of the rTMS effects beyond the 3-week treatment period was not known. The possibility of long-lasting treatment effects, as has been observed with short-term electroconvulsive therapy, could have significant clinical and economic implications for further utilization of rTMS for anxiety.

J Clin Psychiatry 2009;70(3):431-432