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Accurate Meta-Analytical Assessment of "True Antidepressant Effects" Needed

J Clin Psychiatry 2005;66(9):1192-1192 [letter]

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Sir: In their recent article, Posternak and Zimmerman1 question whether there is a several-week delay in “true antidepressant effect.” They propose to address this issue by a meta-analysis to determine (1) “whether significant drugplacebo separation occurs during the first 2 weeks of treatment” and (2) “whether the timing of response to antidepressant medication and placebo is distinct.”1(p148) Since the issue centers on “true antidepressant effects,” measures and analyses must address this salient point.​