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Combining Clozapine and Xanomeline/Trospium Chloride: Mechanisms of Action and the Genesis of Catatonia

September 25, 2026

Warren Cheng, MD Candidate, on a case where abruptly stopping clozapine while continuing Cobenfy (xanomeline-trospium) preceded severe catatonia, and the rebound-cholinergic hypothesis that may explain the risk as Cobenfy…

Original Research

Inpatient Perspectives on LAIs

September 24, 2026

In this pilot sample, patient perspectives on LAI medications during psychiatric hospitalization were heterogeneous and characterized by substantial openness and uncertainty rather than fixed resistance.

Tanya Alim, Allea Frazier, Michelle Brooks, et al

Case Report

Kratom-Induced Serotonin Syndrome

September 24, 2026

A 38-year-old man on a stable regimen of psychotropic medication developed serotonin syndrome after heavy kratom use.

Talya Kapenstein, Alëna A. Balasanova

Academic Highlights ▶ Video

Treatment-Resistant Depression as a Dynamic Continuum: A Consensus Panel Report

September 23, 2026

The panelists reframe treatment-resistant depression as a dynamic continuum and provide a four-stage framework that takes clinicians from initial detection through high-acuity interventions.

Anita H. Clayton, Michael Asbach, Patricia Cabrera, et al

news

Generalized Anxiety Disorder After 65: What the Screening Evidence Does and Does Not Cover

September 23, 2026

Anxiety screening in adults 65 and older lacks sufficient evidence, as data on GAD screening tool accuracy and treatment effectiveness remain limited.

Academic Highlights

Targeted Treatment of Agitation in Alzheimer’s Dementia

September 22, 2026

The panelists provide recommendations to give primary care clinicians a practical, evidence-based guide for managing agitation in Alzheimer’s dementia, and the confidence to apply it.

Pierre N. Tariot, Leslie Citrome, Carolyn K. Clevenger, et al

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Neural network illustration exploring psychedelic therapy mechanisms

Psychologist Elizabeth Ballard, PhD focusing on suicide risk assessment

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Original Research

Psilocybin-Assisted Therapy for Bipolar II Depression

September 21, 2026

Following the 10 mg session, MADRS scores improved significantly, with 4 participants (28.5%) meeting remission criteria and therefore not proceeding to the 25 mg session.

Amanda E. Downey, Balázs Szigeti, Ellen R. Bradley, et al

Original Research

The Role of Chronic Anhedonia in the Relationship Between Treatment-Resistant Depression and Suicidality

September 21, 2026

Chronic anhedonia is significantly associated with an increased risk of suicidal ideation and attempts in patients with treatment-resistant depression.

Tia Sternat, Irvin Epstein, Kathryn Fotinos, et al

Original Research

Bilateral tDCS Reduces Relief Craving During Alcohol Withdrawal

September 17, 2026

Ten sessions of bilateral transcranial direct current stimulation over the dorsolateral prefrontal cortex applied during the active withdrawal period and not modified by dependence severity significantly reduced relief craving…

Twinkle Sharma, Priya Ranjan Avinash, Robin Victor, et al

The Journal of Clinical Psychiatry

The Journal of Clinical Psychiatry is a leader in peer-reviewed articles on mental health topics for psychiatrists and medical professionals. Now featuring The JCP Podcast: conversations with experts exploring the research shaping clinical care. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>

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Podcast

Six Decades of Schizophrenia Care with Nina Schooler, PhD

September 22, 2026

Dr. Nina Schooler traces six decades of schizophrenia research, from early antipsychotic trials to tardive dyskinesia, long-acting injectables, and RAISE.

Nina Schooler, Ben Everett

Correction

Correction. Evaluation of Sexual Function With Adjunctive Lumateperone in Patients With Major Depressive Disorder

September 17, 2026

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The Primary Care Companion for CNS Disorders

The Primary Care Companion for CNS Disorders seeks to advance the clinical expertise of primary care physicians and other health care professionals who treat patients with mental and neurologic illnesses.

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