The article you requested is


J Clin Psychiatry 2005;66(suppl 8):3-4

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Despite recent advances in the understanding and management of depression and anxiety, these disorders remain a challenge for the practicing clinician. As many as one third of patients with depression do not respond to monotherapy with an antidepressant.1 The human and economic impact of depression remains high; unipolar depression is expected to become the most common cause of disability in developed countries within the next several years.2