Is the Problem of a High Placebo Response Unique to Antidepressant Trials?

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Recent studies questioning the effectiveness of antidepressants have received considerable attention in the mass media. These articles report the difficulty in demonstrating superiority of antidepressants over placebo among antidepressant trials. Interestingly, placebo response also plays a significant role in trials of other nonpharmacologic somatic treatments for depression as well as treatments for many other chronic psychiatric and nonpsychiatric illnesses; however, this does not seem to have received similar attention.​

J Clin Psychiatry 2008;69(12):1979-1980