Adding Lithium or Anticonvulsants to Antipsychotics for the Treatment of Schizophrenia: Useful Strategy or Exercise in Futility?

Clinicians often go to heroic lengths to find effective treatment strategies for their patients suffering from treatmentresistant schizophrenia. These approaches include polypharmacy with other antipsychotics as well as adjunctive medication strategies with mood stabilizers such as lithium or anticonvulsants. The hope is for an enhancement of pharmacodynamic effects so that treatment response is perhaps quicker in onset, more robust, and enduring.

J Clin Psychiatry 2009;70(6):932-933