Treatment of Social Phobia With Antidepressants
Franklin R. Schneier
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This article reviews evidence for the utility of antidepressant medications in the treatment of social
phobia. Monoamine oxidase inhibitors (MAOIs) were the first antidepressants shown to be effective
for social phobia, but dietary restrictions and a relatively high rate of adverse effects often relegate
MAOIs to use after other treatments have been found ineffective. Reversible inhibitors of monoamine
oxidase (RIMAs) hold promise as safer alternatives to MAOIs, but RIMAs may be less effective and
are currently unavailable in the United States. Selective serotonin reuptake inhibitors (SSRIs), of
which paroxetine has been the best studied in social phobia to date, have recently emerged as a firstline
treatment for the generalized subtype of social phobia. The SSRIs are well tolerated and consistently
have been shown to be efficacious in controlled trials.
J Clin Psychiatry 2001;62(suppl 1):43-48
© Copyright 2001 Physicians Postgraduate Press, Inc.
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