Commentary

Dr Rosenbaum comments on the challenge of evaluating trials of treatments whose effects are unmistakable, and how this dilemma may be addressed.

Drs Rush and Tramontin discuss how simple outcomes, often patient reported, could facilitate evidence-based decision making by clinicians, administrators, and payors and provide the foundation for a learning health...

Dr Freeman discusses the understudied phenomenon of pregnancy-related extreme dysphoria or depression, distinct from typical major depressive episodes. Three illustrative case vignettes are presented.

Dr Geoffroy discusses recent research exploring the links between suicide and sleep disturbances.

Dr McIntyre discusses the implications of recent research by Baek et al.

Kozak and Aaronson discuss challenges in implementation of MDMA-assisted therapy, including insurance and Medicare coverage as well as cultural barriers.