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Educational Activity

Augmentation and Combination Strategies in Resistant Depression

J. Craig Nelson

Published: June 18, 2009

This CME activity is expired. For more CME activities, visit
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders

Article Abstract

A minority of patients with depression achieves remission with first-line antidepressant treatment; consequently, a second medication is often added to enhance the effects of the initial agent. The second medication may or may not be another antidepressant. Clinical trials have assessed the efficacy of many agents commonly used for augmentation or combination therapy, but well-designed, large trials with a clear definition of treatment resistance are needed.

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