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Letters to the Editor

Bipolar Depression Associated With Fenfluramine and Phentermine

Jennifer E. Zimmer and Robert J. Gregory

Published: July 15, 1998

Article Abstract

Sir: Fenfluramine and phentermine have often been used in combination for the treatment of obesity. Although the Physicians’ Desk Reference lists depression as a potential adverse effect of fenfluramine, it is not contraindicated in the treatment of patients with comorbid mood disorders. We present the case of a woman with a history of bipolar disorder who developed a major depressive episode following administration of fenfluramine and phentermine.

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