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Free Online Activities

Effective Agents in Treating Bipolar Depression

Andrew A. Nierenberg, M.D.

Published: October 31, 2008

This CME activity is expired. For more CME activities, visit CMEInstitute.com.
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders



Article Abstract


Individuals with bipolar disorder may spend about half of their time euthymic, but recurring mood episodes are common and are predominated by depressive symptoms. Despite the prevalence of depression in bipolar disorder, evidence suggests that antidepressants are not likely to benefit most patients. Lithium has long been the first-line treatment for bipolar disorder, but it is not the most effective agent for treating bipolar depression. This activity reviews multiple pharmacologic options that should be considered by clinicians treating bipolar disorder.


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