This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letters to the Editor

Blood Clozapine Levels Elevated by Fluvoxamine: Potential for Side Effects and Lower Clozapine Dosage

Scott C. Armstrong and James R. Stephans

Published: November 15, 1997

Article Abstract

Letter to the Editor

Sir: We report a case in which very high blood clozapine
levels occurred during concomitant use of fluvoxamine. Previous
reports have indicated that close monitoring should be done
when these two medications are coprescribed because of
fluvoxamine’s ability to inhibit hepatic microsomal enzymes
that metabolize clozapine. However, on the basis of this case
and the microsomal enzyme profiles of these two medications,
we believe that extreme caution is warranted.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 58

Quick Links: Bipolar Disorder , Mood Disorders

Sign-up to stay
up-to-date today!


Already registered? Sign In

Clinical and Practical Psychopharmacology

Antipsychotic Augmentation With N-Acetylcysteine for Patients With Schizophrenia

Dr Andrade discusses whether or not recent findings support the use of NAC as antipsychotic augmentation in...