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Letter to the Editor

Comments on a Randomized, Double-Blind Comparison of Sertraline and Placebo for Posttraumatic Stress Disorder in a Department of Veterans Affairs Setting

Hadi M. Hussain, MD

Published: March 18, 2008

Article Abstract

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Sir: Selective serotonin reuptake inhibitor antidepressantsare first-line pharmacologic treatments of posttraumatic stressdisorder (PTSD).1,2 Robust effects have been seen in previouslarge studies of sertraline in civilian populations.3,4 The recent(May 2007) study by Friedman and colleagues5 failed to findevidence of efficacy of sertraline in a veteran population, despitea comprehensive analysis of potential moderator variables.’ ‹

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