This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


The Failure of Evidence-Based Medicine to Guide Treatment of Antidepressant Nonresponders

Michael E. Thase, MD

Published: December 15, 2006

Article Abstract

Because this piece does nothave an abstract, we have provided for your benefit the first 3 sentencesof the full text.

Depression is one of the world’s greatest healthproblems,1 and prompt recognition and vigorous treatment to remission are the best means to reduce theglobal illness burden, increased mortality, and untold sufferingassociated with depressive disorders. As I have reviewedelsewhere, dozens of randomized controlled trials(RCTs) have documented that antidepressant pharmacotherapy,the most widely used treatment for depression,has limited efficacy.2-5‘ ‹

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 67

Quick Links: Depression (MDD)

Sign-up to stay
up-to-date today!


Already registered? Sign In

Case Report

Safety and Tolerability of Concomitant Intranasal Esketamine Treatment With Irreversible, Nonselective MAOIs: A Case Series

Three cases suggest that concomitant use of intranasal esketamine with an irreversible, nonselective MAOI is safe in...