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Letters to the Editor

Can Long-Term Antidepressant Use Be Depressogenic?

Rif S. El-Mallakh, Courtney Waltrip, and Christopher Peters

Published: April 30, 1999

Article Abstract

Letter to the Editor

Sir: We appreciated the thoughtful review on the loss of antidepressant efficacy by Byrne and Rothschild. We would like to put forward another possible explanation for the observation: long-term antidepressant use may be depressogenic. While this idea seems counterintuitive, there are reasons to seriously consider it.


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