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Sir: I call to your attention that the combining form tachymeansswift or rapid and that tachyphylaxis has been defined asa "rapidly decreasing response to a drug or physiologically activeagent after administration of a few doses."^1(p1656)That led me to question the use of the term tachyphylaxis bySolomon et al., in their recent article, to describe "recurrencesof major depression despite maintenance pharmacotherapy,"^2(p283)especially since the median time to recurrence was 31 weeks—hardly "tachy." Admittedly, poop-out leaves something to bedesired as a way of communicating among professionals, butrather than distorting the meaning of tachyphylaxis, perhapsbradyphylaxis would be the better term. Ferrier³ made the samepoint a few years ago, but no one seemed to be listening.’ ‹