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Management of Patients With Treatment-Resistant Depression

Michael E. Thase, MD

Published: March 14, 2008

Article Abstract

Treatment-resistant depression can be attributed to multiple causes, including nonadherence to medication and medical and psychiatric comorbidities. Selecting the appropriate strategy for a patient with treatment-resistant depression, whether it be a single antidepressant, a combination of medications, or a nonpharmacologic method, depends on a correct determination of the cause of the patient’s resistance to treatment.

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