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Partial Responders to Antidepressant Treatment: Switching Strategies

Maurizio Fava

Published: July 21, 2009

This CME activity is expired. For more CME activities, visit CMEInstitute.com.
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders

Article Abstract

In the STAR*D trial, approximately two thirds of patients with depression did not remit after the initial antidepressant monotherapy treatment. The most favorable option for antidepressant nonresponders is switching medications. Partial responders may prefer augmenting the initial medication with a second agent, but in some cases, such as when intolerable adverse events occur, switching may be the appropriate strategy. Methods for switching vary and choosing the appropriate approach will depend on factors such as whether or not the new medication is in the same antidepressant class as the initial agent, the potential for drug interactions, and the severity of side effects.


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