This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Academic Highlights

Role of Mirtazapine in the Pharmacotherapy of Depression

 

Published: August 31, 2000

Article Abstract
Academic Highlights: Role of Mirtazapine in the Pharmacotherapy of Depression.

Over more than 30 years, evidence has accumulated confirming the hypothesis that norepinephrine and serotonin play pivotal roles in the mechanism
of action of antidepressant drugs, stated Dr. Alan F. Schatzberg. Many antidepressants from distinct pharmacologic classes are currently available, but all affect one or both of these neurotransmitter systems. The first antidepressants—the tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs)—act mainly on noradrenergic and serotonergic systems, but their affinity for other neuronal systems, such as cholinergic, α1-adrenergic, dopaminergic, and histaminergic, and quinidine-like effects contribute to their poor tolerability profiles. In contrast, the selective serotonin reuptake inhibitors (SSRIs: e.g., fluoxetine, citalopram, paroxetine, sertraline) have no effect on norepinephrine, and affinity for other receptors differs between the
individual agents.

Volume: 61

Quick Links: Depression (MDD)

Continue Reading…

Subscribe to read the entire article

$40.00

Buy this Article as a PDF

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Original Research

Young-Adult Social Outcomes of Attention-Deficit/Hyperactivity Disorder

ADHD that persisted into young-adulthood was associated with poorer outcomes in terms of education, employment, and emotional...

Read More...