Metformin for Weight Loss and Control in Patients With Mood Disorder

Jonas L. Linneke, MD; Gitte K. Jørgensen, MD; and Claudio Csillag, MD, PhD

Published: October 28, 2014

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Two-thirds of patients in long-term treatment with a second-generation antipsychotic (SGA) experience weight gain. Weight gain might be due to receptor blockade to H1 receptors (as with tricyclic antidepressants) and to 5-HT2C receptors, impaired metabolic regulation, down-regulation of appetite suppression, and less physical activity due to sedation. Metformin promotes the decrease of glucose absorption, suppression of gluconeogenesis in liver, stimulation of glucose uptake in skeletal muscle, and augmentation of insulin activity.

Volume: 75

Quick Links: Side Effects-Medication , Weight

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF

Sign-up to stay
up-to-date today!


Already registered? Sign In

Original Research

Frontothalamic Circuit Abnormalities in Patients With Bipolar Depression and Suicide Attempts

To identify potential markers for suicide risk, this fMRI study looked at neural activity in bipolar depression...