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An Efficacy Analysis of Olanzapine Treatment Data in Schizophrenia Patients With Catatonic Signs and Symptoms

Ferenc Martényi, MD; Stephen Metcalfe, MSc; Barbara Schausberger, Dipl-Ing; and Martin R K Dossenbach, MD

Published: February 1, 2001

Article Abstract

Thirty-five patients suffering from schizophrenia, as diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were preselected from 7 clinical trials according to a priori criteria of catatonic signs and symptoms based on 3 Positive and Negative Syndrome Scale (PANSS) items: scores for PANSS item 19 (mannerism and posturing) and either item 4 (excitement) or item 21 (motor retardation) had to exceed or equal 4 at baseline. This particular patient population represents a severely psychotic sample: mean ± SD PANSS total scores at baseline were 129.26 ± 19.76. After 1 week of olanzapine treatment, mean PANSS total score was decreased significantly (-13.14; p < .001), as was mean PANSS total score after 6 weeks of olanzapine treatment (-45.16; p < .001); additionally, the positive subscale, negative subscale, and mood scores improved significantly. A significant improvement in the catatonic signs and symptoms composite score was also observed at week 6 (-4.96; p < .001). The mean ± SD daily dose of olanzapine was 18.00 ± 2.89 mg after 6 weeks of treatment. The present data analysis suggests the efficacy of olanzapine in the treatment of severely ill schizophrenic patients with nonspecified catatonic signs and symptoms.

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