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Educational Activity

Evidence for the Use of <span style="font-variant:small-caps;">l</span>-Methylfolate Combined With Antidepressants in MDD

Maurizio Fava, MD; Richard C. Shelton, MD; and John M. Zajecka, MD

Published: August 15, 2011

Article Abstract

Helping patients with major depressive disorder achieve symptom-free remission with antidepressant therapy remains challenging. In this activity, 3 investigators discuss the results of a 2-trial, multicenter, randomized, double-blind, placebo-controlled study of adjunctive l-methylfolate, the bioavailable form of folate, in patients who had inadequately responded to an SSRI. The efficacy of doses of 7.5 mg/d versus 15 mg/d is examined, and the safety and tolerability of l-methylfolate are compared with those of other adjunctive treatments. Different types of folate are explained, and the characteristics of patients who might benefit from adjunctive l-methylfolate are proposed.


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The Journal of Clinical Psychiatry
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